WMicroTracker-One可用于测量在液体培养基和多孔板中培养的寄生线虫的运动活性。

传统的测量寄生线虫驱虫效率的方法既费力又低通量。WMicroTracker可用于多种寄生线虫的文库筛选和药物发现。

WMicroTracker ONE已针对以下寄生物种进行了测试和验证：

Species	Stage	Lenght in µm
Echinococcus granulosus (5)	protoscolex	200
Mesocestoides corti (1,4)	tetrathyridia	750-1000
Haemonchus contortus (3,7)	L3	730-805
Cooperia oncophora (3)	xL3	865-940
Teladorsagia circumcincta (3)	xL3	830-865
Ostertagia ostertagi (3)	xL3	850-915
Dirofilaria immitis	larvae	300
Brugia pahangi (2)	microfilariae/ L3	177-230 / 1000-2000
Schitosoma mansoni (2)	schistosomules	110
Meloidogyne incognita	J2	350-450
Angiostrongylus cantonensis (6)	L3	425-524
Heligmosomoides polygyrus (8)	egg hatching – L1 – L2	300-600

 

1.The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs. 
Hugo R Vaca, Ana M Celentano, María A Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira , María C Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit. PLoS Negl Trop Dis. Mar 2021.

2.In vitro screening methods for parasites: the wMicroTracker & the WormAssay. 
Emma Gunderson, Christina Bulman, Mona Luo, Judy Sakanari. microPublication Biology. July 2020.

3.Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites. 
Liu M., Landuyt B., Klaassen H., Geldhof P., Luyten W. Veterinary Parasitology. 2018 Dec.

4.Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. 
Rosenzvit MC et al. PLoS Negl Trop Dis. Feb 2018.

5.The nervous and prenervous roles of serotonin in Echinococcus spp. 
Camicia F, Herz M, Prada LC, Kamenetzky L, Simonetta SH, Cucher MA, Bianchi JI, Fernández C, Brehm K, Rosenzvit MC. Int J Parasitol. Jul 2013.

6.A validated high-throughput method for assaying rat lungworm (Angiostrongylus cantonensis) motility when challenged with potentially anthelmintic natural products from Hawaiian fungi. 
Randi L. Rollins, Mallique Qader, William L. Gosnell, Cong Wang, Shugeng Cao and Robert H. Cowie. Parasitology. 2022 Mar 3;1-28.

7.High-Throughput Phenotypic Assay To Screen For Anthelmintic Activity On Haemonchus Contortus. 
Aya C. Taki, Joseph J. Byrne, Tao Wang, Brad E. Sleebs, Nghi Nguyen, Ross S. Hall, Pasi K. Korhonen, Bill C.H. Chang, Paul Jackson, Abdul Jabbar, and Robin B. Gasser. Pharmaceuticals 2021, 14, 616.

8.Antihelminthic Activity of Lophira Lanceolata on Heligmosomoides polygyrus Using an Automated HighThroughput Method. 
Yamssi Cédric , Noumedem A C Nadia,  Simeni N Sylvain Raoul, Samuel Berinyuy,  Mounvera A Azizi , Tientcheu N J Sandra , Ngouyamsa N A Sidiki , and Vincent K Payne. Journal of Tropical Medicine 2023. 

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